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DIPHENHYDRAMINE hydrochloride, 50mg/ml, 1ml, vial

https://unicat.msf.org/cat/product/97372
STD DINJDIPH5V-

Valid Article

The product is supplied (and stored) sterile, it must remain sterile until its use. Sterile = state of being free from all living microorganisms.
3 - Antiallergics and medicines used in anaphylaxis
Classification of the medicines in groups and subgroups according to their therapeutic use. The classification used by MSF is based on the WHO Model List of Essential Medicines.
R06AA02
Anatomical Therapeutic Chemical Classification according to WHOCC
PM
The order of this product needs to be justified and is only acceptable under certain conditions.
1525
Thermosensitive codes are defined for storage and transportation temperature requirements of the products.
OC subscriptions: included in supply or field order tools (e.g. UniField)
SC subscriptions: included in supply or field tools
OC validations: approved for procurement and use by an OC for international or local orders specifying context and activity in Medical Standard Lists (MSL)
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DIPHENHYDRAMINE

Therapeutic Action

First-generation H1 antihistamine with a rapid onset of action, acting as a competitive antagonist of histamine receptors.

Diphenhydramine is a potent antihistamine agent with antipruritic, anticholinergic (antispasmodic), antiemetic, and sedative properties.

Indications

First-line, rapid-acting treatment of acute dystonic reactions caused by antipsychotic medications (neuroleptics) in patients over 2 years of age.

Allergic reactions to blood or plasma, in anaphylaxis as an adjunct to epinephrine after acute symptoms are controlled, and for allergic conditions when oral therapy is impossible or contraindicated.

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Instructions for use

Must be given by IV or IM route.

Posology in adult for treatment of acute laryngeal dystonia:

  • 50 mg by IV or deep IM route.
  • If administered by IM route, a second dose may be given after 30 min.
  • Maximum daily dosage is 200 mg

Diphenydramine injectable may be used as an alternative to promethazine injectable in case of supply issue.

Precautions for Use

Contraindicated in case of :

  • glaucoma
  • urinary retention (of prostatic or other origin)
  • decompensated heart disease

Contraindicated in neonates, premature infants, and in breast-feeding women.

Common side effects include somnolence (drowsiness), dizziness, and dry mouth.

Storage

  • Below 25ºC
  • After opening, use the product immediately.